Grissom, Sara and Brass are called to Sparks State Psychiatric Hospital when a nurse discovers one patient murdered with his skull smashed in, and another huddled in the opposite corner, covered in blood.
When Jim Brass receives a rare phone call from his daughter Ellie, he takes emergency leave and travels to Los Angeles to help her find a friend who has disappeared.
Sara and Greg investigate the death of two naked students at WLVU, who clearly died after a night of lovemaking. What is not clear is what turned their bodies pink, after carbon monoxide and cyanide have been ruled out as cause of death.
A lonely and frustrated Catherine meets the wrong man in a bar, but doesn't admit to the encounter - even when he turns up as the lead suspect in what may be a double homicide.
A deadly bomb explosion at a Vegas office building sends Grissom and the CSI team in search of a serial bomber. Their primary suspect is the building's overly helpful security guard, who knows more than he should about blowing things up.
Grissom and Catherine investigate when a leg is found severed from a body in a lake. Meanwhile, Sara and Nick investigate a fraternity pledging gone terribly wrong.
Grissom and Brass track down a serial killer who stages his murders so that they appear to be suicides. Meanwhile, Willows and Brown investigate a robbery and a homicide.
Catherine violates department protocol when she takes the case of a rape accusation against her ex-husband. Meanwhile, Warrick and Sara search for the missing bullet that will either exonerate or indict a cop for murder.
The CSI team works backwards from the gruesome discovery of a human eyeball to discover that a missing woman has been murdered, and both her husband and teenage daughter have shocking motives to want her dead.
Grissom and his crew handle their highest profile case to date when the city's former chief of detectives is slain execution-style in his house following a wild party.
A woman's head is discovered in a newspaper dispenser, and when Dr. Robbins does his post-mortem he finds a startling clue - a dead snake resting in the victim's mouth.
A feverish night in Las Vegas results in one dead male in an alien suit, one more dead male in a bathtub, one dead female with two suspicious men at the scene, and another dead male with a polaroid of yet another dead male.
A casino employee is beaten and raped on her way home from work, but she survives and identifies her attacker. Grissom and his team struggle to find the physical evidence to convict the perpetrator when it points in a different direction.
Grissom is called to investigate the murder of a 17-year-old in a casino penthouse. The entire team gets involved when it's discovered that a kidnapping took place along with the murder.
Grissom is shocked to discover the prime suspects in his ongoing homicide investigation shot to death in their house. But what is more surprising is that their murder points to an inside job.
When Grissom and Warrick arrive at a burglary scene, they are shocked to discover the mummified corpse of an elderly woman locked in a closet from a prior home invasion.